Sentence examples for leads to inability from inspiring English sources

Moreover, patients with COPD have impaired laryngopharyngeal sensitivity, which leads to inability to detect pharyngeal residue and subsequent aspiration of pharyngeal contents [ 15].

Inactivation of either spkC, spkF, or spkK, leads to inability of cells to phosphorylate GroES, suggesting the existence of a regulatory circuit or cascade, in which these three STPKs interact with each other.

Although LSDs were first classified on the basis of lysosomal enzyme deficiency that leads to inability to metabolize lipids, glycoproteins or glycosaminoglycans, there are now many LSDs that include deficiencies in lysosomal transmembrane proteins, soluble non-enzymatic lysosomal proteins and proteins important for trafficking to or from lysosomes (34, 38– 40).

Additional hints for the organization of fibronectin molecules within the fiber lamellae are provided from our denaturation experiments (Table 2), which showed that loss of secondary structure either prior or after fiber formation leads to inability for fiber assembly or fiber dissolving, respectively.

In contrary to mesophilic and thermophilic counterparts, if the cold-active enzyme is too rigid or too stable with low flexibility, the low activation free energy value (Δ G#) may not be able to be overcome so that the activity cannot be promoted and thus leads to inability of the enzyme to perform the catalytic activity.

Hence, short telomeres can lead to inability to maintain epithelial integrity leading to emphysema (Alder et al, 2011).

This is due to the non-similarity characteristics in vehicles, which lead to inability of the gateway to access.

During the fast cascade stage, inadequate situational awareness led to inability to take timely emergency control measures.

All these effects may lead to inability to capture the important physical instability in natural circulation systems and instability characteristics i.e. amplitude and frequency of flow oscillation.

The argument for time-targeted VOT is that maximal ischemic vascular response is reached within a few minutes of VOT [37] and that long vascular occlusion times could lead to inability to complete VOT procedure due to subject discomfort [38].

Lesion may also lead to inability to open the eye due to disrupted innervation of the levator palpebrae (unlike in Horner syndrome, which only results in a droopy eyelid).