Ejby, Denmark; N = 4 TG females, 3 WT females) express the human 695 isoform of APPswe, which leads to expression of mutant Aβ, Aβ plaques and memory deficits.
Many carry randomly integrated transgenes expressing the mutant protein, an approach that generally leads to expression levels that are much higher than endogenous levels (Dossena et al., 2008; Friedman-Levi et al., 2011; Hsiao et al., 1990; Yang et al., 2009).
This is apparently different from negative regulation of Elf5 by RUNX1, in which loss of Runx1 leads to expression of Elf5 even in basal cells in which Elf5 is normally not expressed.
The ABA content is increased by abiotic stresses, and leads to expression of numerous genes.
Activation of the PPARg pathway leads to expression of adipose differentiation-related protein (Adrp or perilipin 2, Plin2) by LIF.
Within the ileal enterocyte bile acids induce expression of nuclear farnesoid X receptor (FXR); this in turn leads to expression of fibroblast growth factor 19 (FGF-19).
The Boston Globe noted, "The first view of the new Columbian souvenir coin inevitably leads to expression of regret that Columbus wasn't a better looking man".
With respect to HIV-1 infection, Tat exposure of microglia leads to expression of iNOS as well as NO production [72].
In many imprinted genes, antisense transcription from CpG islands within an imprinted gene leads to expression competition causing promoter methylation and silencing [10].
We show that dsDNA stimulation leads to expression and secretion of TNFα, as well as upregulation of surface adhesion molecules that facilitate leukocyte recruitment.
Aberrant glycosylation of glycoproteins and glycolipids on tumor cells leads to expression of abnormal tumor associated carbohydrate antigens (TACAs) [61], [62].
