Sentence examples for leads to developmental from inspiring English sources

Disruption of signalling leads to developmental abnormalities and disease, including cancer.

On the other hand, overexpression of Hoxb4 in mouse developing oocytes leads to developmental delay at the transition between one to eight cells, and the same trend is also observed at morula/blastocyst stages.

Cardiac-specific deletion of LKB1, an upstream AMPK kinase, leads to developmental hypertrophy and dysfunction [40], while ablation of another AMPK kinase TGF-β-activated kinase-1, TAK1, causes embryo midgestation lethality [78].

To demonstrate that AP2C3 expression leads to developmental perturbation of epidermal cells, we have studied the lines with inducible AP2C3 expression under the control of estrogen receptor-regulated expression system (XVE-AP2C3).

Mutating or deleting insulators alters the pattern of gene expression and leads to developmental defects [ 51].

A decrease in abundance of the 21 nt variant reduces miR168 homeostasis and leads to developmental defects.

Even then, widespread failure by drivers and passengers to make use of the belts led to developmental work on passive-restraint systems.

S1 exposure led to developmental deficits during the zebrafish ontogenesis.

Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer.

Our understanding of the health effects of Mn exposure to humans is also evolving, and recent research indicates that elevated Mn concentrations in drinking water may lead to developmental disorders in children, among other adverse health effects [6 9].

Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging.