Sentence examples for leads to blockade from inspiring English sources

Furthermore, DIM attenuates experimental arthritis by the inhibition of the receptor activator for nuclear factor κB ligand (RANKL), which leads to blockade of osteoclastogenesis [ 126].

8 Recent studies have revealed that elevated GABA in the murine model of SSADH deficiency (aldh5a1 −/− mice) leads to blockade of mitochondrial mitophagy associated with enhanced oxidative damage.

33 Initial in vitro studies by Honiberg et al using mouse models of rheumatoid arthritis and lupus demonstrated that selective inhibition of BTK leads to blockade of B cell signaling.

1) CAP binds to HIV-1 virus particles and to the envelope glycoprotein gp120; 2) this leads to blockade of the gp120 V3 loop and other gp120 sites resulting in diminished reactivity with HIV-1 coreceptors CXCR4 and CCR5; 3) CAP binding to HIV-1 virions impairs their infectivity; 4) these findings apply to both HIV-1 IIIB, an X4 virus, and HIV-1 BaL, an R5 virus.

Platelets, in fact, play a key role in atherogenesis, and its thrombotic complications and measures, which lead to blockade of one or multiple pathways modulating platelet activation and aggregation processes, are pivotal in reducing ischemic risk in diabetic subjects (4).

Pretreatment with MPP did not lead to blockade or augmentation of the inhibitory effects of ICI on PRL release.

Increased inhibition can lead to blockade of LTP induction in the hippocampus (Ji et al. 2001) and an increase in the threshold for induction of spike timing dependent plasticity (Couey et al. 2007).

Inhibition of Smo leads to the blockade of Hh signaling, and therefore represents a promising approach toward novel anticancer therapy.

This is relevant because regular human consumption of caffeine leads to the blockade of about half of the body's A1 receptors.

VEGF inhibition leads to a blockade of the capability of endothelial cells to regenerate, causing endothelial dysfunction [ 65].

Furthermore, HMGB1 acetylated by LPS or PCAF is a substrate for SIRT1, and deacetylation of HMGB1 by SIRT1 leads to a blockade of HMGB1 release.