Sentence examples for leads to a switch from inspiring English sources

Oxidative stress increases expression of AGE and RAGE (receptor for AGEs) leading to an activation of NF-κB which leads to a switch in the gene expression of cardiac MHC (myosin heavy chain) from the α-MHC isoform to the β-MHC isoform altering myocardial contractility [ 104].

Hence, when canonical TGFβ signaling is robust, E7 levels are low; E7 levels rise during progression from HKc/HPV16 to HKc/DR and this leads to a switch in TGFβ signaling from canonical (growth inhibitory) to non-canonical (promoting EMT) [74].

In melanoma cell lines, expression of miR-200 members does not suppress invasion but rather leads to a switch between modes of invasion.

The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1 3 are dissociated from the promoter, and E2F4 and p130 are recruited.

Depletion of carbohydrate sources in the distal colon leads to a switch from saccharolytic to proteolytic fermentation, which is less favorable due to the formation of potentially toxic products.

For example, prolonged treatment of Ph+ CML and ALL cells with imatinib frequently leads to a switch from dependence on ABL signaling to dependence on src family kinases [39].

O2− ion migration because of lower barrier height for electrons leads to a switching mechanism based on filament formation/rupture.

Thus, the presence of both the repression mechanisms for expression of Gal1p leads to a switch-like response to glucose, with the expression residing either in the completely expressed or repressed states.

He added that enabling local people to profit from wind power would lead to a switch in "deeply subjective aesthetic perceptions".

His abilities would lead to a switch to AVV Zeeburgia three years later, before being picked up by AZ in 2004.

Irradiation with UV light led to a switch in wettability of the film from superhydrophobic to hydrophilic and this process could be reversed by subsequent irradiation with visible light.