Compounds 2, 8, 15 and 18 were screened to act as leads for further modification and use.
These bioinformatics approaches and their associated methodologies, which can be applied across a range of technologies, facilitate the rapid identification of new target leads for further experimental validation.
We have obtained derivatives with good cytotoxic activity, in particular, the derivatives 5c and 6b could represent two novel leads for further investigation.
Although the anticancer activity of (4f) and (4u) is not comparable as standard drug activity, the functional group modifications at the substituted benzimidazole and pyrido imidazole can guide to upgrade the drug leads for further investigations from this laboratory.
Limitations to our analyses provide leads for further research.
Therefore, this gives leads for further epidemiological research using additional information at household spatial scale within the study area.
Although the number of small RNA sequences may not be sufficient for the analysis to be quantitative, overall trends suggest leads for further analysis.
These will be important in the use of these compounds, particularly HNK, as it leads for further development of drugs targeting GRP78 to induce ER stress in cancer cells.
"That material was then written up in FBI files as possible leads for further investigation.
So far, we have whittled these down to around 100 promising leads for further investigation, throwing up references on everything from rendition flights and economic predictions for Ireland to mentions of David Beckham and Roman Polanski.
In composing the following list, I'm inevitably overlooking worthwhile items, but here are a few leads for further reading on Chinese art, dissent, and literary life: Karen Smith, the curator and critic, has done invaluable work on Chinese art for years, including a long essay last year about Ai Weiwei in a book from Phaidon Press: "Ai Weiwei" (2009).
