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New libraries were synthesised in order to concentrate on discovering new, shorter peptides which could be leads for developing peptidomimetics.
Due to both their commercial availability and their fairly straightforward synthetic preparation, these low molecular weight compounds are attractive leads for developing future angiogenic inhibitors.
The multitarget profile of the novel hybrids makes them promising leads for developing anti-Alzheimer drug candidates with more balanced biological activities.
This work offers promising leads for developing RIP therapeutics.
These peptides can be used to detect Mcl-1 dependency in cells and provide leads for developing Mcl-1 targeting therapeutics.
It provides several leads for developing a generic PROM questionnaire in primary care as well as for potential limitations of such instruments.
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This may provide access to a new lead for developing ERK1/2 substrate-specific inhibitors.
Hence, 47 exhibits potent anti-cancer effects on HCC cell lines, and is a suitable lead for developing multi-targeted kinase inhibitors of relevance to HCC.
Since LY294002 thus exerts versatile inhibitory effects on the ABC transporters that characterize stem cells and cancer stem cells (Figure 5), it can be a lead for developing more effective and tolerable reagent for cancer treatment.
These results seem to confirm the ability of this inhibitor to bind simultaneously to both sites of the enzyme and make it a promising lead for developing disease-modifying drugs for the future treatment of Alzheimer's disease.
Compound 33 (IC50 = 23 nM) exhibiting promising oral pharmacokinetic parameters (AUCinf = 7058 ng*h/ml, T1/2 = 0.83 h) coupled with 87percentt reduction of plasma triglycerides in vivo may serve as a lead for developing newer anti-obesity agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com