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Diarrhea leading to testing was common in both groups, but adults appeared to experience more testing for C. difficile (Fig. 4).
It is likely that there have been changes in data collection methods over the study period, for example, changes to the assay used for rotavirus laboratory testing, leading to testing bias.
It is likely that these two recommended policy changes would be viewed as ethical if they increased the number of people tested without leading to testing of individuals who were unaware of or did not agree to testing.
We excluded studies if the study authors used active case detection to recruit participants, as we felt the threshold of symptoms leading to testing may be lower than for a self-selecting sample attending healthcare facilities and that this may influence the findings.
The fact that adrenalectomy as well as hypophysectomy was an effective antitumor therapy albeit at a cost of high morbidity motivated trials on 'medical adrenalectomy', leading to testing of glucocorticoids (Kofman et al. 1958, Lemon 1959), as well as adrenal enzyme inhibitors like ketoconazole (Harris et al. 1988).
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In 2005, auto-recycling waste ignited at a landfill near Livermore, leading to tests by the San Francisco Bay Area Regional Water Quality Control Board that detected leachable toxins.
But she only made the link with Parkinson's after meeting other sufferers, and happened to mention it to a scientist at a talk, leading to tests which found her sense of smell was accurate.
These lifestyle changes may reduce reflux events leading to test results that underestimate disease severity [ 1, 2].
Because the test can produce false positives, leading to more testing, the debate can be contentious.
Mr. Kwiatkowski tested positive for the same strain, leading to the testing of thousands of patients in New Hampshire this summer.
In an essay in The British Medical Journal in December, Dr. Nicholas A. Christakis, a professor at Harvard Medical School, argues that an "overreaction" to allergy is leading to unnecessary testing and false positives.
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