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However, optimal geometries of excited states have not been successfully calculated due to too demanding computer requirements and at the same time these calculations could be a topic of the next research leading to specification of excitation transitions.
Thus, we had a situation where important explanatory variables were left out of the estimated regression equation 2 (in the Appendix), leading to specification bias or omitted variable bias [ 21].
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Experiments using a variety of model organisms have pointed to a conserved gene regulatory network leading to hematopoietic specification, with the transcription factor scl representing one of the central genes in the hematopoietic specification cascade.
For instance, if a neuron will be generated, genes that govern the specification and differentiation of that particular subtype of neuron during development—such as Delta-Notch signaling or pathways leading to subtype specification, axonogenesis, or synaptogenesis become active again.
Nuclear translocation of adenylate kinase and p-AMPK supported energy-dependent cell division, and facilitated asymmetric differentiation leading to cardiac specification.
Previously, Lim3 was found to be active in the Drosophila embryonic nervous system and to take part in regulatory networks leading to the specification of motor neuron subclass identity, axon pathfinding, and finally, proper muscle innervation [12].
Using rat as a model, the authors showed that the translation of DPYSL2B mRNA is localized in the axon and is regulated by mTOR through the action of its effector, 70-kDa ribosomal S6 protein kinase (p70S6K), leading to the specification, formation, and maintenance of the axon.
This indicates the key position of FGFs as upstream regulators of genetic pathways leading to germ layer specification during the late blastula to early gastrula stage of amphibian development.
The standard SELEX procedure schedules the validation of certain found aptamers via binding experiments, which is not leading to any detailed specification of the aptamer enrichment during the screening.
A Tsunami effect in manufacturing, the effect of propagation of manufacturing deviations leading to out-of-specification products, was not observed with these pre-packed columns.
Risks leading to out-of-specification results or delay of supply of biologics may be mitigated by judicial selection of appropriate single-use components, by setting their specifications, by carrying out appropriate design, evaluation, and control measures for their use in the manufacturing of biologics.
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