Sentence examples for leading to mutation from inspiring English sources

Using this system, we demonstrate that homing endonucleases can efficiently and selectively target an integrated reporter lentivirus within the cellular genome, leading to mutation in the proviral DNA and loss of reporter gene expression.

DNA damage leading to mutation and death.

They may also inhibit DNA repair mechanisms leading to mutation and carcinogenesis (Burney et al, 1997).

Such effects on DNA result in cross-linking of base pairs leading to mutation of a gene.

Hydroxyl radicals are well known cause for damaging biological macromolecules leading to mutation, cancer and age-related diseases [ 15].

In contrast, high NO concentrations such as those made by activated macrophages, cause extensive damage to nearby biomolecules leading to mutation, cell death and tissue damage.

However, this binding to DNA will cause replication errors in living tissue, possibly leading to mutations and cancer.

However, the high activity of the enzyme also often leads to an increased fitness burden on the host, limiting the predictability of its interactions and impact on host physiology, and potentially leading to mutations in the constructs.

If left unchecked, these lesions can block ongoing replication, leading to mutations, genome rearrangements, and even cell death [1].

These molecules can form adducts with cellular DNA, leading to mutations in vital genes like Ras, p53, and Rb [2], [3], [4].

ROS cause oxidation of DNA bases leading to mutations during replication.