Sentence examples for leading to modified from inspiring English sources

SERCA expression levels can undergo significant changes during cell differentiation or tumorigenesis, leading to modified ER calcium storage.

Our results are consistent with the idea that normal FGFR3 signal transduction in SrAp cells is altered by the p.gly380arg mutation, leading to modified stem-cell self-renewal patterns that confer a proliferative advantage compared with adjacent non-mutant cells.

However, various animal studies have shown that prenatal sGC exposure can lead to alterations in the development of a number of organ systems leading to modified function throughout life (6, 7).

Furthermore, and recently, there has been a development of local anesthetics skin-delivery systems using lipid nanoparticles, and this technique has been channeled into commercial formulations such as lidocaine and prilocaine cream, leading to modified release rate of drugs, increased bio-adhesive abilities, and reduced toxicity, thereby improving therapeutic potency [46].

More general limitations of self-reporting methods such as log books, administration reports, interviews and questionnaires include being subject to social desirability bias [ 93], potentially leading to modified reporting of MAEs [ 21].

For example, on a spatial scale of a few to tens of kilometres, larger sensible heat flux caused by reduced transpiration could cause a decrease or even increase in cloud formation (D'Almeida et al. 2007; Knox et al. 2011), leading to modified radiation and thus altered surface energy balance, altered evapotranspiration and also altered stomatal conductance (effect 2.1 in Fig.  2).

They postulated that extensive alteration of thoracic structure might change the cyclic variation of intrathoracic pressure, leading to a modified heart lung interaction.

Reactivity is further reduced by reaction with methanol or diethylene glycol (producing ultra-low formaldehyde release) leading to ether modified DMDHEU products with low formaldehyde release (Holme 1993).

An imperfect interface is introduced between the particles and the matrix through a linear spring model LSM, leading to a modified Eshelby's tensor.

Dietary lipid hydroperoxides that escape from the gastrointestinal barrier can be incorporated into plasma lipoproteins, leading to a modified form of LDL LDLL minus).

Using linear elastic fracture mechanics, the influence of load ratio on fatigue crack growth rate was studied; leading to a modified Paris Law equation based on strain energy release rate range, ΔG, and mean value of strain energy release rate, Gmean.