"leading to difficulty" is a valid phrase that can be used in written English.
You can use it to describe a situation that arises from the choices or events leading up to it, which creates a difficult situation. For example: The more he procrastinated on his project, the more issues began to arise, leading to difficulty in completing it on time.
Accordingly, inhibition of one enzyme may lead to compensatory activity by the other leading to difficulty in ascertaining the normal roles of these enzymes.
As a result, only large stools will be perceived, leading to difficulty with defecation. 4 In the elderly, chronic constipation can lead to fecal impaction and fecal incontinence.
Their Fourier spectra have a complex sideband structure, leading to difficulty in feature extraction and fault diagnosis.
Those might include poor reading comprehension leading to difficulty in understanding maths problems, for example; or missed classes and misunderstood lessons causing knock-on, diagnosable problems later on.
However, the fate of nitrogen in aquaponic systems has not been fully understood, leading to difficulty in optimizing nitrogen use efficiency (NUE) and plant production.
High-risk patients with advanced disease, including critical limb ischemia (CLI), are often excluded leading to difficulty in translating trial results into real-world clinical practice.
For example, a patient with diabetes may also have food insecurity, leading to difficulty accessing food that will help his medical condition and resulting in more hospitalizations for diabetes.
Planetary gearboxes vibration signals are highly complex due to the intricate kinematics and the amplitude modulation and frequency modulation nature, and their spectra have intricate sidebands, leading to difficulty in planetary gearbox fault identification.
While it is a proper tool for modeling complex system designs involving timing, sequencing, repair, redundancy, and fault tolerance, as the complexity or size of the system increases, so does the number of states of interest, leading to difficulty in constructing and solving the Markov model.
