Sentence examples for leading to different phenotypes from inspiring English sources
These transcriptional changes correlated well with functional data on cell proliferation, expression of adhesion molecules, and utilization of metabolic pathways, ultimately leading to different phenotypes.
The differences in tumor multiplicity and latency among transgenic lines generated with the same transgene construct might rest in the random integration of the transgene into the mouse genome, leading to different phenotypes and levels of transgene expression depending on the site of integration and on the number of transgene copies.
In addition, IS insertions upstream of protein coding sequences can result in their enhanced expression, leading to different phenotypes depending on the function of the over-expressed gene.
At the same time, the number of rare BMP4 variants seen in patients with variable phenotypes may suggest a contributory/sensitizing role for BMP4 missense mutations leading to different phenotypes depending on other genetic variants/mutations present in the affected individuals.
Loss of Ubiad1 and Coq2 in vivo unequivocally causes a decrease in CoQ10 levels that possibly increases oxidative damage in different subcellular compartments leading to different embryonic phenotypes.
Atherosclerosis is a disease affecting arterial blood vessels, leading to different disease phenotypes depending on the anatomical location and stage of the disease process.
The dominant feature at the cellular level was the occurrence of 'oncogene-dependent' follicular cell changes, leading to different cellular phenotypes, small cells in the E7 model and large cells in the RET/PTC3 model, which evolved differently with time.
The discrepancy may be explained by different cellular sources of the DC precursors leading to different immature DC phenotypes.
Taken together, the same gene mutations leading to different syndromes or diseases with different phenotypes tell us the importance for gene diagnosis, genetic counseling, and clinical management, such as personalized medicine in our medical genetic practice.
As the Srs5 mutant does not exhibit a twisted phenotype, different mutations in alpha-tubulin seem to lead to different phenotypes.
This main feature of our model is in line with the general view of the Rac-Rho-system leading to different and mutually exclusive cellular phenotypes [ 10].
