Sentence examples for leading to developmental from inspiring English sources
A number of mouse mutants affecting miRNA regulation through Dicer have been created, leading to developmental inner ear defects [ 10, 11].
Loss of NF2 function in the dorsal telencephalon of the murine brain also elicited increased Yap/TAZ activation and increased cell proliferation/expansion leading to developmental defects [101].
They exhibited either a G2/M block or, more frequently an abnormal mitotic spindle leading to developmental arrest.
Contrary to expectations, our data show that an L11 deficiency activates the p53 pathway leading to developmental abnormalities, apoptosis, and embryonic lethality.
Taken together, these results suggest that BPA impact on the somatotropic axis functioning during early embryogenesis as a mechanism leading to developmental and growth impairment in juveniles.
Together, these results indicate that hlyA has a specific role in eliciting intestinal vacuolation during V. cholerae infection in C. elegans that may represent a crucial step in pathogenesis leading to developmental delay and lethality.
For example Killifish embryos decrease their developmental rates leading to a developmental arrest in early stages of development in response to desiccation [ 56].
Petit speculates that EYA1 mutations in people suppress the production of the EYA1 protein, leading to the developmental defects.
The presence of an extra copy of chromosome 21 in Down syndrome sufferers may disrupt this hyperactive methylation, leading to such developmental abnormalities as mental retardation, Kao suggests.
As one potent plant protease inhibitor, potato carboxypeptidase inhibitor (PCI) can competitively inhibit insect digestive metallocarboxypeptidases (MCPs) through interfering with its digestive system that causes amino acid deficiencies and leading to serious developmental delay and mortality.
Targeted deletion of miR-208, while not leading to a developmental defect, blocked the heart's ability to develop a hypertrophic response to stress [16].
