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The phrase "leading to a decrease" is correct and usable in written English.
You can use it to refer to something that is causing a decline or reduction in a certain amount or level. For example, "The closure of the factory is leading to a decrease in local employment opportunities."
Exact(60)
The increase in Cr3+ ions at the B site leads to replacement of Fe3+ ions at B site, leading to a decrease of ferrous ions formed.
Lead disrupts mitochondrial phosphorylation and oxidation within the kidney, leading to a decrease in energy-dependent transport.
A chronic increase in HIF-2α leads to high turnover of the tight junction protein occludin, leading to a decrease in barrier integrity [17].
You write that many college administrators worry that the new emphasis on single-bedroom living on campus is leading to a decrease in social activity.
Build quality is crucial as devices have shrunk in thickness while their screen sizes have continued to grow, leading to a decrease in rigidity.
The financial crisis continues to impact the economy there, most recently leading to a decrease in French car sales.
These defects work as recombination centers, leading to a decrease in carrier concentration.
Desogestrel increased baseline respiratory frequency of CCHS patients leading to a decrease in their PETCO2.
This is shown to be a driving-force leading to a decrease in the corrosion resistance.
Municipal wastewater contains compounds like sulfur and organic matter leading to a decrease of sequestration (lines 27 29).
Thus, as the temperature increases, the number of adsorbed molecules decreases, leading to a decrease in the inhibition efficiency.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com