Sentence examples for leading synthesis from inspiring English sources

The result of this three polymerase reaction is consistent with and anticipated from our earlier study of leading synthesis using primed forks (i.e., no Pol α) in which we demonstrate that Pol δ is inefficient and distributive on the leading strand and that Pol ε suppresses Pol δ by taking over the 3′ primed site in the CMG-dependent leading strand reaction (Georgescu et al., 2014).

In contrast, no DSBs are generated if uncoupling of continued lagging-strand synthesis with stopped leading strand synthesis occurs.

The G-strand and C-strand of telomere DNAs are invariably replicated by leading strand synthesis and lagging strand synthesis, respectively.

It has already been proposed that they could both participate in the DNA synthesis at the replication fork, the B-family polymerase for leading strand synthesis and the D-family for Okazaki fragments synthesis [63].

On the other hand, Polδ and Polε are believed to extend these short primers; Polδ is mainly responsible for lagging strand synthesis while Polε is thought to be responsible for leading strand synthesis (reviewed in [3], [7]).

We propose that this is because SSB cannot trap the junction bases coordinately with DNA synthesis in the manner that T7 helicase does during leading strand synthesis.

At one end, the new strand is the product of leading strand synthesis while at the other end, it is the product of lagging strand synthesis.

The discontinuous lagging strand is a more difficult process than continuous leading strand synthesis, and the current study aims to identify how polymerases are coordinated during coupled leading lagging strand synthesis.

Five of the world's leading gene synthesis companies today announced steps they are already implementing or plan to implement a plan to prevent misuse of the technology.

Moreover, there exist some successful examples in which these models have been able to predict and guide experiments, leading to synthesis of catalyst materials with improved activities.

Key cytoplasmic proteins of this machinery leading to synthesis and local deposition of cell wall material are distributed around the hemispherical end (see for example [9] [11]).