This sequence is repeated throughout thermal cycling leading to substantial material loss from the centre of the front face of the thermally cycled samples.
The insufficient level of financial security means that families and individuals have a significant health expense burden, leading to substantial financial difficulties [ 5, 6].
Decellularization of thick tissues and organs usually requires strong chemicals (acid/base, detergents, and enzymes), leading to substantial deformation of the scaffold and loss of ECM molecules.
One dietary intervention known to have substantial impact on physical health and behaviour is a diet restricted in calories (leading to substantial reductions in particularly carbohydrate intake).
These artifacts induce substantial SUVmax overestimation compared to the reference SUV for PSF algorithms at SBR1 and SBR2 leading to substantial MTV underestimation in threshold-based segmentation.
But in recent months there has been a "substantial weakening in the delivery of structural reforms," which has undermined hopes for stronger economic growth, "leading to substantial new financing needs".
But in women, estrogen drops off sharply after menopause, leading to substantial risk of osteoporosis.
Somalia has not had a stable government since 1991, leading to substantial logistical and safety challenges when reporting in the region.
Anthropogenic sources currently account for approximately 70 percent of total annual emissions, leading to substantial increases in concentration over time.
"Over the past several years, the world economy has expanded at its fastest pace in decades, leading to substantial increases in the demand for oil," Mr. Bernanke said.
