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It is also suggested that high nuclear accumulation of KPNA2 leads to cytoplasmic retention of NLS-containing cargo proteins due to defective import: the transporter factor KPNA2 is not recycled back to the cytoplasm to transport the next karyophile into the nucleus leading lack of 'free' KPNA2 to bind its cargo in the cytoplasm (Gorlich and Mattaj, 1996).
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Moreover, endpoint definitions, especially for the composite ones, varied substantially among studies, leading to lack of homogeneity.
This blocks the intake of air through the mouth and nose, leading to lack of oxygen and, occasionally, death.
In local construction practice of hilly region, the binding material used is mud mortar which is the prime cause leading to lack of structural integrity and poor bonding of housing units.
The goal of this chapter is to revisit data warehousing as we know it today, and the issues that have confronted the world of data warehousing leading to lack of adoption and often failure of data warehouses.
This approach allowed the identification of critical modifications in the EspP subtypes β and δ leading to lack of proteolytic activity.
Inhibition of PIK3CD activity reduces VEGF activity leading to lack of vascular permeability [ 22].
Thus, clinicians viewed parental resistance as leading to lack of family involvement.
The truncating mutation causes loss of three quarters of the protein leading to lack of interaction with the RAD51 protein.
Cystatin C expression is found reduced in AAA disease, leading to lack of inhibition of the elastolytic properties of cathepsins.
First, all included studies were observational ones, leading to lack of random allocation of the intervention compared with RCTs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com