The nine columns correspond to the pathway name, the size of pathway, ES score, NES score, nominal p value, FDR q value, FWER p value, and leading edge (typical GSEA output).
The nine columns correspond to the pathway name, size of the athway, ES score, NES score, nominal p value, false discovery rate (FDR) q value, FWER p value and leading edge (typical GSEA output).
Extract Leading Edge Matrix: leading edge matrices of various types can be extracted from a GSEA result; the leading edge matrix is comprised of GSEA leading edge genes (in rows) from all gene sets in the result (in columns) passing a specified FDR threshold with rank metric score, rank in list, or boolean membership values as the matrix fields.
The nine columns correspond to the pathway name, size of the pathway, Enrichment score (ES) score, Normalized enrichment score (NES) score, nominal p value, false discovery rate (FDR) q value, Family-wise error rate (FWER) p value, and leading edge (typical GSEA output).
For α Da ≥1, the capture zone saturates near the leading edge, yielding a n/ N value near unity.
As gene set enrichment analysis mainly computes upon the leading edge of the ranked P-value vector of genewise differential expression (see Subramanian et al., 2005), gene sets with a majority of activating genes are more likely to be reported.
However, when all the in-line boards are naphthalene coated, the calculated mass-transfer coefficients decrease in an approximately asymptotic manner from a maximum value near the leading edge of the first board.
The fitting range was set to 80% of the peak value on the leading edge and 20% on the falling edge [ 28].
Indeed, among the 94 genes flanking the microsatellites>9R, 30 were at the leading edge (Z-score = 8.6, Fisher p-value = 2.1×10−11).
For example, there is a two order of magnitude decrease in chemical time scales at the leading edge of the front relative to its unstretched value.
