Sentence examples for leading edge assembly from inspiring English sources

Regulation of leading edge assembly and cell migration by factors downstream of small GTPases and PI3Ks is also accomplished by activation of numerous kinases, such as ROCK, PAK or LIM Kinase-1 (LIMK1) [6].

Clearly, ancient proteins involved in motility, such as WASP-family proteins, have evolved features that allow them to promote epithelial cell organisation when they need to be restricted from nucleating leading edge actin assembly and we propose that gaining a deeper understanding of these features would make a valuable contribution to our understanding of EMT and cancer spread.

The underlying defect is not leading edge F-actin assembly (prominent in the cells of the envelope layer), but rather the failure to localize E-cadh and β-catenin at the adherens junctions.

We propose that these multi-layered interactions at the leading edge guide the assembly of the actin nucleation and elongation machinery into supramolecular complexes to coordinate their activities for the efficient construction of force-generating actin networks.

We first measured paxillin dynamics in the cytoplasm, where it is present as single molecules or in very small aggregates, and then measured paxillin binding and unbinding to adhesions at various loci in the cell, including adhesions near the leading edge during their assembly and disassembly.

The failure of the 15F mutant to stimulate actin flux implicates SD tyrosine phosphorylation as the primary mechanism by which p130Cas promotes actin assembly at the leading edge.

Actin assembly at the leading edge of migrating cells is thought to be facilitated by profilin's (Pfn's) interactions with G-actin and various promoters of actin nucleation and F-actin elongation [ 1, 2].

Thus, the selective disassembly of non-tensed stress fibers is crucial for cell migration; e.g., cell migration is partly realized by the continual processing of actin fiber dynamics, including disassembly at the trailing edge and assembly at the leading edge of cells.

However the SD mutational variant was fully defective in increasing actin assembly at the protruding leading edge and FA assembly/disassembly rates, indicating that SD phosphorylation is the sole p130Cas signaling function in regulating these processes.

Stabilization and persistence of the lamellipodia depend on the assembly of FXs at the leading edge of the lamellipodia.

Because of its importance for normal cell physiology, numerous players contribute to the assembly and organization of the leading edge actin network.