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Interestingly, active p130 CAS, paxillin and ERK have been implied to be critical for the nascent adhesion turnover at the leading edge, a process that is key to the cell migration [12].
The localized formation of FAK protein complexes gives origin to nascent focal adhesion sites at cellular leading edge, a process that facilitates cell polarization in the direction of cell migration.
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Migrating cells assemble dynamic focal adhesions at the leading edge in a process that crucially depends on the spatial activation/inactivation cycles of focal adhesion kinase (FAK) [17], [18].
"Although at the heart of what we're doing is we're building a processor, we're building our own chip — leading edge process, 16 nanometer — we're actually going to deliver that as a system solution, so we'll deliver PCI express cards and we'll actually put that into a chassis so that you can put clusters of these IPUs all working together to make it easy for people to use.
Speaking of chip manufacturing, logic kingpin Intel (NASDAQ INTC) is now farming out leading edge process for the first time in decades as its seeks to undercut the mobile Internet ARM-based incumbents and get its nose under Apples tent.
The advance of Moore's law and the increasing complexity and heterogeneity of established and leading edge processes along with increasing robustness and dependability requirements further kindle the interest in efficient analog electronics design automation.
"This is the leading edge in a shift in thinking about domestication processes".
Actually the flow field at the leading edge of a cavitating hydrofoil can be representative of the flow over the leading edges of a real cavitating impeller.
We are on the leading edge of a cultural shift.
At the leading edge of a migrating cell, rapid actin polymerization is required for lamellipodia formation.
The interaction between FAs and actin network is complex, in particular due to the fact that actin network in most migrating cells is not stationary with respect to the substrate, but moves away from the leading edge of the cell in a process known as retrograde flow [7], [8].
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CEO of Professional Science Editing for Scientists @ prosciediting.com