These alterations would affect pathways leading to alterations in aerobic metabolism (Fig. 2), a hallmark of cancer cells, and give further evidence of the role of Wwox as a surveyor of the cell's metabolic status.
It is therefore now increasingly clear that changes in critical trafficking pathways can induce alterations in cell surface proteins leading to alterations in polarity and susceptibility to further steps that may lead to transformation.
It also alters LDL particle size, thus leading to alterations of the lipid profile known to be associated with increased cardiovascular diseases.
Proteolysis is a critical modification leading to alteration of protein function with important outcomes in many biological processes.
Chemical-induced epigenetic alterations leading to altered gene expression are probably involved, in particular in relation to in utero effects.
The products of polyunsaturated fatty acids (PUFAs) peroxidation, such as malondialdehyde (MDA), can form adducts with nucleic acids and proteins thus, leading to alterations in their functioning.
Cleavage of OPN by PC5/6 may modify the function of OPN in bone and/or modulate other enzymatic cleavages of OPN, leading to alterations in the bone phenotype.
This connection between theory of mind and the internal working model may open new areas of study, leading to alterations in attachment theory.
These results indicate that NEFH regulates mitochondrial function, leading to alterations of cellular respiration and glycolysis.
In the future, genetic manipulations leading to alterations of the adult visual system will be increasingly used.
