Moreover, the structural breaks and the temporal effects of the series can be identified and modeled leading to a model with a better fit to the data.
In other words, the assumption behind CPD analysis that the same stimuli elicit the same response in all subjects was violated, leading to a model which did account for the subject specific differences.
Incubation of human cdc25C with Xenopus mitotic extracts also increased phosphatase activity leading to a model where an auto-amplification loop involving cdc25C and cdk1/cyclin B may be implicit in mitotic activation [16].
Transcriptional and RNA processing machinery can be observed at the surfaces of territories, leading to a model in which active genes loop away from the main body of the chromosome to be transcribed in the interchromosome domain [32].
More than two functional donor or acceptor sites can occur leading to a model of unbounded size.
All two-way interactions were tried, but none found to be significant leading to a model described by the equation 1 in Supplementary Material 1.
Reciprocally, K36 trimethylation inhibits the activity of Fpr4, leading to a model where genes can be activated quickly through the combined action of Fpr4 and Set2.
Model building and refinement then continued with PHENIX (Adams et al., 2010), with automated building and morphing routines leading to a model comprising approximately 50% of the PfRh5 sequence.
This was done twice for every endospore matrix combination (for B. anthracis only baking powder and bird sand) leading to a model database with a total of 5723 Raman spectra (Table S2 a in the Supporting Information).
An important feature of the algorithm is that it uses the expression of Boolean functions as polynomials, leading to a model search space that has a rich mathematical structure that can be exploited.
A similar localization and function has been described for CEP290 in Chlamydomonas (39), leading to a model in which transition zone proteins restrict the entry of non-ciliary proteins into the cilium.
