Sentence examples for leader domain from inspiring English sources

Such sequence alignment revealed high conservation of the leader domain, as opposed to the hyper-diversification of the mature domain.

Furthermore, the human single-chain IL-12 contains a secretory leader domain, resulting in efficient secretion independent of posttranslational processing and p35 subunit glycosylation [ 54, 55].

Accordingly, it was hypothesized that in scorpions, selection could underlie both hyper-diversification of the mature toxin and conservation of the toxin leader domain.

Opposite to the mature toxin residues, the majority of the leader domain residues showed very strong (62%) negative selection, with only 5% being under the effect of positive selection forces and 33% being neutrally selected.

While segregation of the different gene families is clearly observed in the leader domain (Fig. 3B, left plot), most transcripts diverge directly from the origin of the mature domain tree (Fig. 3B, right plot).

The tight cluster of the leader domain tree, versus the star-like shape of the mature domain tree, demonstrates that the same pattern of conserved leader and diverse mature peptide sequence exists in all of the distinctive toxin families.

These data thus demonstrate that scorpion toxins gene families can be defined primarily on the basis of their highly conserved leader domains, in combination with distinctly conserved cysteine patterns, as was previously suggested for other scorpion species [ 16].

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When examining separately the phylogenetic trees of the mature and the leader-coding domains (Fig. 2B, C), the leader-coding domain seemed to segregate even earlier than the mature toxin-coding domain.

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Indeed, Boi toxin intron nucleotide diversity exceeds that of the leader-coding domain but is much lower than that of the mature toxin coding domain (Fig. 6A, B).