Traditionally, Mn2+ is delivered to animals via a systemic injection; however, this can lead to toxic effects at high doses.
Leaks in water pipes can waste up to half the water in a system; oil-pipeline leaks can lead to toxic spills and prolonged, expensive cleanup operations.
Combining drugs might allow for synergy in restoring chloride movement, but it might also lead to toxic interactions, as with any combination therapy.
In addition, local staphylococcal infections can lead to toxic shock syndrome, a disease associated with the liberation of a toxin into the bloodstream from the site of infection.
For a therapy to be successful it is therefore mandatory that inactivation of HIF1 and HIF2 in adult photoreceptors and RPE does not lead to toxic effects.
A diverse range of molecular interactions can occur between engineered nanomaterials (ENM) and biomembranes, some of which could lead to toxic outcomes following human exposure to ENM.
In the case of persistent oral infections, the dosages of conventionally delivered antiviral, antibacterial and antifungal medications can lead to toxic side effects.
Different therapies, including drugs, proteins and stem cells, could treat scarring but these treatments struggle to stay at their intended target, often require multiple doses, and could lead to toxic side effects.
Different therapies, including drugs, proteins and stem cells, could treat scarring but these treatments struggle stay at their intended target, often require multiple doses, and can lead to toxic side effects.
The Census reports a dominant missense mutation in TSHR that is associated with thyroid adenoma, and studies have shown that constitutive activation of TSHR by somatic mutations can lead to toxic thyroid adenoma43,44,45.
Although higher incorporated AA level contributed to enhanced metabolic activity and biosynthetic capacity of keratocytes grown on cryogel matrices, the presence of excessive amounts of AA molecules could lead to toxic effect and limit cell proliferation and matrix production.
