Sentence examples for lead to the impairment from inspiring English sources

5-Fluorouracil (5-Fu) is commonly used chemotherapy drug, but it can lead to the impairment of cognitive function.

Whether long-term MMT could lead to the impairment of white matter (WM) in heroin addiction brain is unclear.

The smooth muscle segment of the esophagus was less compliant in older subjects, but there was no significant difference in compliance of striated esophageal muscle between the groups.61 These changes could lead to the impairment of peristalsis noted in the elderly.

Phe209 is positioned on TM6 and F209A probably lead to the impairment of conformational flexibility required for transport activity (Fig. 6B and Fig. S4).

The analysis of gills of fish and bivalves has been widely used because changes in this organ may lead to the impairment of several functions, including gas exchange, ion regulation and excretion of metabolites (Cruz et al. 2015).

Overall, these findings suggest that even acute exposure to SHS during pregnancy (14 days; day 1 group) may lead to the impairment of crucial proteostasis/autophagy mechanisms potentially rendering the neonate/pediatric population more susceptible to pulmonary diseases such as BPD.

It was suggested that nocturnal life leads to the impairment of insulin response to glucose.

Taken together, our results indicate that Rag2 KI mice exhibited enhanced accumulation of thymocytes at the DN stage and led to the impairment of thymocyte development at the DN-to-DP transition.

To further verify if the combinatorial treatment leads to the impairment of tumourigenicity of colorectal cancer stem cells in vivo, we performed tumour xenograft experiments under the limiting dilution conditions.

MDSCs are generated and/or activated during an inflammatory immune response and negatively affect T cells through direct interactions and secreted components, which leads to the impairment of T-cell function.

Taken together, these observations suggested that the loss of high-threshold mechanical response of AMH nociceptors (Aδ-fiber) by elimination of TRPV2 led to the impairment of mechanical nociception of PSN-specific TRPV2-deficient mice.