Sentence examples for lead to the altered from inspiring English sources

Naturally; it needs to be further investigated if these are the variants that lead to the altered splicing.

This negative regulation can impair PTPN11 activity and lead to the altered PDGFRA signalling involved during the commitment of oligodendrocytes, astrocytes, and neuroprogenitors [ 20].

This inhibition of the SOX genes might lead to the altered collagen and aggrecan synthesis typical of IVD degeneration [ 7- 10, 53].

The aberrant expression of miRNAs in cancer can lead to the altered expression of target mRNAs.

Through MD and QM/MM simulations, we were able to demonstrate substrate dynamics involving multiple free energy wells that lead to the altered product distribution.

We hypothesised that, during ageing and degeneration of the disc, the chondrocyte-like disc cells become senescent, resulting in phenotypic changes that can lead to the altered cell function and extracellular matrix characteristic of disc degeneration.

Understanding the mechanisms that lead to these altered on/off patterns and how to reverse them can pave the way to new therapies and more efficient treatments--a bright future indeed for molecules once dismissed as the genome's dark matter.

Such effects could lead to the development of altered neuromuscular control patterns and potentially, to an increased risk of re-injury.

This may be particularly important in a healthy plaque environment where stimulating the inflammatory response will lead to the generation of altered physiological conditions that other species (particularly other Porphyromonads) may be better adapted to utilize.

Comparing methylomes across cancer types might now help to identify novel non-recurrent mutations converging on common biological pathways that might lead to the development of altered methylation phenotypes in specific subgroups of cancers.

Upon reproduction, for each site a mutation can lead to the expression of the altered gene product as a public good.