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At higher concentrations, saturation effects, brought about by the approach of active radicals to their equilibrium concentrations, lead to substantial decreases in the effectiveness of high efficiency suppressants in comparison with their effects at small concentrations.
In summary, it is evident that exercise in sufficient amounts can lead to substantial decreases in body weight, total body fat, and visceral fat.
The implementation of such policies contributing to the improvement and quality of public transport (e.g., network, infrastructure and vehicles), sustainable mobility infrastructure (e.g., more and safer bicycle lanes and pavements) and options offered (e.g., attractive and affordable car/bike sharing/pooling schemes) can lead to substantial decreases in GHG emissions.
Phospholipids have been discussed as energy source, and short periods of fasting have been shown to lead to substantial decreases in PC and PE species in the heart, but not in muscle [44].
While there have been recent attempts at quantifying levels of confidence in given protein interactions these generally lead to substantial decreases in sample size.
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All the mentioned factors may lead to substantial decrease in the conversion rates.
It is notable that the removal of one of the two ligands from the ectodomain dimer did not lead to substantial decrease in the area of the dimer interfaces, suggesting that, in agreement with recent experimental findings (Liu et al., 2012), a single bound ligand is sufficient to maintain a stable ectodomain dimer of EGFR.
Seeds heavier than 60% of the rodent's mass led to substantial decreases in acorn removal and seeds heavier than 70% of the rodent's mass were in no case removed.
Because of the benefits of herd immunity, vaccinating even a relatively small portion of the target population leads to substantial decreases in disease prevalence and resulting negative sequelae relative to prevaccination rates.
We found that in vivo neutralization of endogenous MCP-1 during acute sepsis led to substantial decreases in the transcript levels for IL-1α, IL-1β, and IL-6, as well as MCP-1 itself, in the diaphragm.
Increase of electron concentration in the channel leads to substantial decrease of its resistance.
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