Sentence examples for lead to structural alterations from inspiring English sources

In a few primary metabolic disorders, small genetic mutations lead to structural alterations of specific proteins that disrupt protein function and are responsible for the disease state.

To facilitate GTP exchange, guanine nucleotide exchange factors (GEFs) bind the GDP-bound conformation of Rabs and lead to structural alterations that facilitate GDP release and allow subsequent GTP binding (3).

Such reactions can lead to structural alteration and/or cross-linking of proteins, which in turn can cause impairment of protein function.

Another important source of mitochondrial O2−depends on Ca2+ influx, often secondary to glutamatergic excitotoxicity, which leads to structural alterations of the inner mitochondrial membrane.

For instance, the polymorphism in exon 2 of the superoxide dismutase 2 (SOD2) gene A16V (C/T) (rs4880) led to structural alterations in the domain responsible to target the mitochondria, giving a reduction in the antioxidant potential [ 26].

Anthracyclines lead to structural cardiomyocyte alterations and cell death, which is probably mediated by reactive oxygen species (ROS) generated in iron-dependent chemical reactions.

The fetal origins hypothesis of Barker states that programming during fetal life occurs in response to an adverse environment and results in permanent adaptive responses that lead to structural and physiological alterations and the subsequent development of cardiovascular disease.

They argue that exposure to stress (ethnic discrimination) results in psychological distress that adversely affects health; that behavioural coping strategies to manage stress may include unhealthy behaviours such as smoking and alcohol misuse; and that psychological and behavioural responses to stressors can lead to structural and functional alterations in physiological systems [ 14].

New installs in those roles could lead to structural changes.

We therefore hypothesized that alterations in the microtubule network might be a consequence of decreased spastin levels in the SPG4 neurons and this might lead to structural defects.

Consequently, removal of all heptad-repeats lead to major structural alterations and corresponding loss of enzymatic activity [59], [60].