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Because of the steep dose response curve of flecainide and the interindividual differences in drug metabolism and half-life, the 20%% difference between products commonly used to define BE can lead to small variations in drug exposure, leading to reduced antiarrhythmic efficacy or adverse effects on patient outcomes.
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Although all paired samples were sourced from the same paraffin embedded tissue blocks, naturally small variations in the tissue within the block will lead to small variation within the pairs.
The identification of compounds from complex mixtures, as in metabolomics, is an intricate endeavor, as metabolite signals overlap and can lead to small chemical shift variations that hinder assignments.
Slight variations in nozzle shapes may lead to small angular deviations of the droplet trajectory.
In many materials the low abundance of Rb and their relatively young age leads to small isotopic variations (e.g. 0.05% in mantle rocks and biogenic carbonates).
Consequently, variations from the assumed form lead to smaller bias.
We note that Treloar et al. found that varying the Matlab edge detection threshold parameters led to a small variation in the position of the detected leading edge corresponding to a cell density in the range of approximately 1 5 % of the carrying capacity density [ 24].
Under too low wind speed, the inconspicuous variation of water film morphology leads to small amplitude of lift and cable vibrating like free vibration.
Thermal evolution in the lab led to smaller flies in hot environments through variation in cell area [ 8, 10, 14].
If the effect of low temperature leads to an increase of body size, the competition for food leads to smaller flies (both effects are mostly mediated by cell area variation).
This led to smaller choices.
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