Although our work here focuses on the role of Tbx1, other genes with roles in early muscle initiation and specification may also lead to similar increased susceptibility.
The USF-1-mediated increase in PGC-1α promoter activation led to similar increases at the mRNA level.
For example, failure to satiate drives for either feeding or mating leads to similar increases in arousal and the expression of appetitive behaviors such as swimming [ 30, 31].
Also, a general increase in the diagnosis of PPH would have led to similar increases in other subtypes of PPH such as PPH caused by retained placenta, secondary PPH, or PPH caused by coagulation defects (Table S2).
We then performed glucose tolerance test and injected a bolus of glucose (intraperitoneal [i.p.], 2 mg/g body weight), which led to similar increases in blood glucose levels in both knockin and wild-type mice 15 min after the injection.
Suppressing PVs led to similar increases in tone-evoked FR between weak and strong tones for both deviant (N = 51, p2 > 0.05, t 50) = 1.0) and standard tones (p2 > 0.05, t 50) = −1.9).
In addition, recent observational studies showed that elective induction leads to similar increased maternal and foetal risks as induction on medical indication, in comparison to spontaneous onset of labour [ 21].
17β-estradiol (E2) treatment led to similar increased ERα activity and treatment with the selective estrogen receptor downregulator fulvestrant, which induces inhibition and degradation of ERα, abolished the E2-induced ERα activity (Additional file 3: Figure S1C).
Because citrullination leads to an additional mass of nominally one Dalton compared to regular arginine residues, such searches are prone to false positives stemming from the misidentification of C isotopes or modifications that lead to similar nominal mass increases (for example, deamidation of asparagines or glutamine).
