Sentence examples for lead to significant difficulties from inspiring English sources

However, lack of substantial operational experience in such a novel process can lead to significant difficulties in identifying the associated hazards.

This broad definition partly relates to uncertainties on actual CHF demographics, and as the yearly admission is unlikely to exceed 500, will not lead to significant difficulties in enrolment.

That can lead to significant difficulty in readjusting to home life".

This problem frequently leads to significant difficulties aside from the primary presenting problem.

The lack of timely feedback shopfloor information during manufacturing execution stage leads to significant difficulties in achieving real-time production scheduling.

This led to significant difficulties and delays in establishing the NHIS policy and its passage through parliament.

This was practical because the GICU, the ED and the operating theatre complex were close together, but with a different floor-plan it might have led to significant difficulty.

Will this lead to significant trouble for the chain?

Contemporary characterisation techniques for graphenes are often performed for samples in a dried state or vacuum, which can lead to significant structural changes and difficulty in assessing the actual physical or physicochemical characteristics of graphenes in a colloid state.

Without intervention, anemia can lead to significant symptoms like fatigue, breathlessness, difficulty in concentration and other effects on functionality and quality of life therefore treatment of anemia in HIV should be aimed at correcting the underlying cause [ 16].

This fully agrees with the results obtained in previous studies [ 21, 36] and suggests that attempts to obtain a very simple clinical model that reduces computation difficulties could lead to significant loss of performance.