Sentence examples for lead to significant alteration from inspiring English sources
Lattice dynamics and MD simulations show that, without a change in the host interatomic potentials, the filler host bonding alone cannot lead to significant alteration of acoustic phonons or lowering of phonon conductivity.
Stainless steel miniscrew (OMI) eluates did not lead to significant alteration in HGF metabolism except for the 1-day extract, when a slight increase was observed at pH 7. On the other hand, at pH 4, a significant decrease was found after 7 and 14 days.
This gives the β-cell cluster some room to tolerate perturbation to its architecture, namely, a small amount of random β-cell loss will not lead to significant alteration of the cluster function.
The loss of any earthworm functional group might lead to significant alterations in the microbial biomass, distribution and physiological profile.
Oxidative aging of asphalt is a constantly occurring chemical process that involves the reactions between oxygen molecules and component species of bulk asphalt throughout its service life, which could lead to significant alterations to the desired physical properties of asphalt.
Because slight variations in physical characteristics of a beach can lead to significant alterations in biota, we minimized confounding physical influences by working only in the predominant shoreline habitat type in Puget Sound, a mixture of sand, pebbles and cobbles.
As Pousielle's law dictates, minor changes in caliber of very small diameter capillaries would lead to significant alterations in blood flow.
In contrast, transient silencing of UPF1 and/or UPF2 in MSI and MSS colorectal cancer cells (HCT116, LoVo, Co115, LS174T, SW480, COLO320) did not lead to significant alterations of cell growth and/or death in our hands (data not shown).
Because melanin is a mixture of negatively charged hydrophobic macromolecules and is abundant on the conidial surface, mutations in melanin biosynthesis could lead to significant alterations in the morphology and cell surface properties.
It is well known that unphysiological cell culture conditions lead to significant alterations of cell characteristics.
MiR-17 overexpression did not lead to significant alterations on the cell morphologies (data not shown).
