Exact(12)
Although the precise molecular mechanism is not yet understood, it is generally thought to result from neuroplastic changes in the peripheral and central nervous systems that lead to sensitization of pronociceptive pathways.
These changes lead to sensitization of the first order trigeminal neurons, explaining pulsating pain, pain aggravated by movements of the head, bending down, and physical exercise [20].
The data point to a biological rather than merely physical mechanism of sensitization, and below we discuss several hypothetic scenarios of what cellular events could lead to sensitization.
Upregulation of TLRs by chronic alcohol treatment can lead to sensitization.
Use of fluoroquinolones and cephalosporins for treatment of other conditions may lead to sensitization of the N. gonorrhoeae isolates in asymptomatic patients with gradual selection of drug resistant strains and eventually clinically significant resistance.
Hypersensitivity is a poorly understood phenomenon thought to result from opioid-induced neuroplastic changes in the peripheral and central nervous systems that lead to sensitization of pronociceptive pathways [ 1, 9].
Similar(48)
Moreover, the current use of extracts of undefined contents can lead to sensitizations against new allergens during conventional immunotherapy [2].
But this has also led to sensitization toward its professional conduct in the public.
Therefore, this medication leads to sensitization against food with changes typical for food allergy also in the intestine.
In the latter case the activity of alkali halides arises after pre-excitation in exciton bands, which leads to sensitization of alkali halides to visible light.
This ultimately leads to sensitization of trigeminal primary afferents, as well as second-order central trigeminovascular neurons [24, 113].
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