Peripheral sensitisation of TRPV1 sensitive nociceptors in turn leads to sensitisation of the central nociceptive system and clinically to mechanical hyperalgesia [1].
Inhibition of MDR-1 led to sensitisation of MDR-1-overexpressing cell lines to YM155 (Lamers et al, 2012).
Therefore, an adenoviral vector expressing rabbit CE was constructed and transduction of human tumour cells led to sensitisation to CPT-11 (Wierdl et al, 2001).
Shattuck et al (2008) showed in a cell line model that attenuation of MET activity leads to sensitisation to trastuzumab, whereas MET activation protects cells from the growth inhibitory effects of trastuzumab by preventing trastuzumab-induced p27 induction.
Similarly, the down-regulation of Bid, also plays a role in establishing the resistant phenotype, since the reconstitution of the high Bid expression in PancTuI and Panc89 cells led to sensitisation of both cell lines to CD95- and TRAIL-mediated apoptosis.
3 4 It is recognised that chronic pain may alter central pain processing, for example, central sensitisation, as the continuous damage of the pancreatic nerves may in time lead to central sensitisation of the pain system.
It is conceivable that a protracted period of coughing due to respiratory tract infection, the use of angiotensin converting enzyme inhibitor drugs [1], or perhaps frequent episodes of primary headache, might lead to peripheral sensitisation, with reduced threshold for trigeminal activation.
5 6 29 Clinically relevant animal models of OA are essential for the identification of the mechanisms which lead to this sensitisation seen clinically.
Additionally, infection during pregnancy [ 6- 8], or antigen exposure through immunisation during pregnancy [ 9], may also lead to immunological sensitisation of the developing foetus to that particular infection or immunogen.
The beneficial effects of nutrition on this activity could thus, in theory, lead to reduced sensitisation to an allergen or mitigation of the severity of allergic responses to non-food-related allergens such as respiratory or contact allergens and so are not necessarily restricted to food allergy.
