Understanding site-specific subchondral bone architecture is important because extreme mechanical load transferred to the osteoporotic subchondral bone may cause microfracture, which may lead to scleroses of the subchondral bone [ 20].
Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints.
It is believed to be caused by recurrent low-grade or subclinical peritonitis, which does not manifest with any significant abdominal signs and eventually leads to sclerosis and membrane formation with subsequent formation of a cocoon [ 14].
These maladaptive changes eventually lead to cell destruction and adhesions between the GBM and Bowman's capsule leading to sclerosis [ 31].
Finally, the hippocampus often is the focus of epileptic seizures, which can lead to hippocampal sclerosis (a pathological loss of hippocampal cells).
Katz et al. [8] proposed that a number of pathological processes cause spondylosis and they lead to vertebral "endplate sclerosis".
The use of new structural MRI diagnostic techniques allows the testing of the intriguing hypothesis that prolonged febrile seizures lead to medial temporal sclerosis.
Since autoimmunity to oligodendrocyte antigens can lead to a multiple sclerosis (MS -like disease in experiMS -likenimals, subsequent studisease neuroprotectinexperimentalanimalsusubsequentcinating with Copaxone® (e.g., [7], [8], [9], [10]).
The accumulation of mesangial matrix may eventually lead to nodular glomerular sclerosis, described first by Kimmelstiel and Wilson [ 16].
Cox, 25, who is aiming to compete in both athletics and cycling at the Rio Paralympics, suffered a stroke in May 2014 which led to Multiple Sclerosis.
