Sentence examples for lead to reversion from inspiring English sources

Intriguingly, Pdaf-28-driven INS-4 alone did not lead to reversion (Fig. 4B, +INS-4 panel, ASI/ASJ).

Since mutagenic properties of gene breaking transposons are brought about by the splice acceptor and polyadenylation/transcriptional termination signals, removal of these components should lead to reversion of the insertional mutation.

In our model, the L. monocytogenes inlA 5' HT, we observed a frequency of insertion of an adenine in the A6 tract (A6 → A7) in the order of 10-7, while the frequency of an adenine deletion in this HT (A7 ->A6) was lower, suggesting that mutation events that lead to reversion to a full length inlA are more common in this HT.

One trial of 180 Italian subjects found the Mediterranean diet intervention to lead to reversion of MetS (3), the other larger trial (n = 1,224, Spanish) suggested that the observed effect was due to the effect of nut supplements rather than the Mediterranean diet as a whole (4).

As the name indicates these mutations are usually seen in patients who have failed and later interrupted therapy with zidovudine (AZT) or stavudine (d4T), which leads to "reversion" of the resistance mutations T215Y and T215F, but nothing precludes that they may be present as minority variants before therapy.

Studies have suggested that these rebounding wild-type variants originate either from wild-type virus that had been archived in latently infected cells before start of therapy [13] or from continued evolution that leads to reversion of resistance mutations [14], [15].

Interestingly, MMP13 expression was reduced in the presence of hypoxia which also led to reversion of the hypertrophic phenotype of OA chondrocytes [ 34].

Overexpression of MnSOD in numerous transformed cell lines leads to reversion of the tumorigenicity in vivo or of the malignant phenotype in vitro [ 49, 50].

The four suppressor mutations were straightforward to detect because they led to reversion of dms4-1 mutant phenotypes (that is, the suppressor mutants were GFP− and had a normal developmental phenotype).

Surprisingly, we observed that the simple placement of tumor cells in complete medium, without the addition of any drug, led to reversion of the down-modulated phenotype (when present) within a few hours (data not shown).

To analyze how this G-to-A substitution leads to reversion of the rpn12a-1 phenotype, we manually compared the consensus sequence for 5´ splice sites in Arabidopsis with the sequence of the exon/intron junction that precedes the RPN12a STOP codon in rpn12a-1 and sor1.