Sentence examples for lead to replication from inspiring English sources

Such imbalances would eventually lead to replication stress at chromosomal regions that replicate late during S-phase such as certain telomeres (Arnoult et al, 2010).

So while it may be tempting to remove oneself from the triangle altogether, Brooks says this will only lead to replication of the same dynamic with other close relationships.

Growth arrest of RAS2val19, rim15Δ and other cells in S phase could be caused by a reduction in the levels of nucleotides and other factors required for efficient DNA synthesis, which would lead to replication stress.

Phosphorylation of H2AX following non-thermal plasma treatment is ATR dependent and ATM independent, suggesting that plasma treatment may lead to replication arrest or formation of single-stranded DNA breaks; however, plasma does not lead to formation of bulky adducts/thymine dimers.

Persistent unrepaired DNA lesions can interfere with DNA replication, which can lead to replication fork stalling and copying errors.

The extent to which dinucleotide microsatellite repeats lead to replication fork stalling has not been previously investigated.

Mus81-deficient yeast cells are very sensitive to the topoisomerase I inhibitor camptothecin, which is believed to lead to replication-dependent one-sided DSBs that can be recovered by HR similar to BIR as drawn Fig.  1 (Pommier 2006).

For example, hyper-proliferation of cells within pre-neoplastic tissue results in reduced intracellular nucleotide pools, which in turn can lead to replication-induced DNA damage and increased genomic instability [ 12].

Severe nucleotide limitation led to replication fork stalling and reversal.

By causing ssDNA, UV treatment also leads to replication fork arrest and induces ATR activity [32].

An important factor determining replicative lifespan is DNA replication stress i.e., inefficient DNA replication that leads to replication fork stalling which stimulates recombination at a replication fork barrier in the rDNA locus ([13] and references therein).