Sentence examples for lead to reduced efficacy from inspiring English sources

In general, a broad distribution of DAR can lead to reduced efficacy, and thus the distribution needs to be tightly controlled.

Such dose decrements often lead to reduced efficacy [ 6].

Development of antibodies against the medication may potentially lead to reduced efficacy and/or changes in the safety profile.

Poor compliance or non-compliance with oral anti-cancer medications is not uncommon in older breast-cancer patients [3 5] and can lead to reduced efficacy of therapy.

Allopurinol, which is the mainstay of chronic gout management [ 16], requires dose adjustments in gout patients with renal impairment [ 17], which may lead to reduced efficacy [ 18].

For instance, the prescription of ticagrelor was restricted to a combination with an acetylsalicylic acid maintenance dose of a maximum of 150 mg, as the results of the Study of Platelet Inhibition and Patient Outcomes (PLATO) had indicated that increased doses of acetylsalicylic acid might lead to reduced efficacy.

Reductions in drug doses may attenuate toxicity but may lead to reduced therapeutic efficacy.

Based on currently available information, rFVIIa can be expected to be useful for the control of nonsurgical bleeding under hypothermic conditions encountered in trauma (e.g. 33°C), but loss of TF dependent activity and decreased platelet function will likely lead to reduced rFVIIa efficacy as temperature approaches 30°C.

Another hypothesis proposes that passive, unchallenging jobs with few demands and little control over work can lead to reduced self-efficacy, which in turn may result in more passive lifestyles (11, 12).

Taken together, the results in this study suggest that hinge cleavage from intact trastuzumab to scIgG-T in the tumor microenvironment may lead to reduced anti-tumor efficacy by weakening the antibody's ability to mediate immune effector functions.

Furthermore, we hypothesize that hinge cleavage from trastuzumab to scIgG-T in the tumor microenvironment may lead to reduced anti-tumor efficacy by weakening the antibody Fc interaction with immune effector cells.