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This might lead to reactivation and vertical transmission of latent viral infections such as BK virus (BKV).
At Little Rock, the planned move will lead to reactivation of the 913th Airlift Group — a reserve unit that was deactivated when its home base at Naval Air Station Joint Reserve Base Willow Grove in Pennsylvania was closed under the 2005 BRAC process.
This is in contrast to ES fusions with female somatic cells, which lead to reactivation of the Xi [27].
In this study, cynomolgus macaques with latent TB were infected with SIVmac251 to investigate the factors that could lead to reactivation of latent TB.
This novel model will be a useful tool for investigating interactions between Mtb and HIV, and the immunologic events that lead to reactivation of latent TB or exacerbation of primary infection.
Based on our study reported here, demethylation of the viral genome, especially of the RTA promoter, would lead to reactivation of MHV-68 into lytic replication and eventual lysis (and loss) of the latently infected cells, and hence may also be responsible for the severe ablation of the viral latency observed.
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It is generally believed that weakening of the immune response against Mycobacterium tuberculosis leads to reactivation of latent infection into the active pulmonary disease.
It is commonly believed that weakening of the immune system leads to reactivation of latent Mycobacterium tuberculosis (Mtb) infection into the active pulmonary disease.
This evidence is provided by both observational and experimental studies on human subjects and contradicts the commonly held view that weakening of immune system leads to reactivation of latent Mtb infection into the active disease.
Indeed, previous experiment in a mouse model for latent TB showed that depleting of CD8 T cells led to reactivation of latent TB [18].
Several studies have shown that abrogating the MDM2-p53 interaction leads to reactivation of the p53 pathway and inhibition of tumor cell proliferation [10], [11].
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