Sentence examples for lead to profound alterations from inspiring English sources

The latter procedure has been shown to lead to profound alterations of the intestinal microbiota [ 23– 25].

Disorders of the nervous system are associated with complex neurobiological changes, which may lead to profound alterations at all levels of organization.

In all embryos there is a close relationship between the process of gastrulation and the establishment of axial structures, as experiments and mutants that disturb the establishment of the axis lead to profound alterations in the specification and movement of the endodermal and mesodermal precursors (Huelsken et al., 2000; Medina et al., 1997; Morkel et al., 2003).

Stimulation of PBMCs with anti-CD3 led to profound alterations in the profile of TSA-mediated cell surface molecule expression.

The drug remarkably reduced protozoan proliferation in vitro and led to profound alterations in the redox organelles termed hydrogenosomes.

PGC-1α overexpression using recombinant adeno-associated virus (rAAV) leads to profound alterations in neuronal metabolic profile, consistent with changes in mitochondrial biogenesis, ATP production, mitochondrial polarization and expression of genes implicated in mitochondrial function.

Importantly, the combined ablation of C/EBPα and C/EBPβ leads to profound alteration in interfollicular epidermis due to increased proliferation of basal cells, defective differentiation and insufficient barrier function [18].

This, he said, would lead to "profound change".

Prenatal inflammation may therefore lead to profound presynaptic alterations in NAcc DA synthesis.

Persistent neuronal excitation by this mechanism may lead to profound neuropathological alterations, including neurodegeneration and cell death.

Inhibition of mTOR leads to profound change in cellular metabolism and attenuation of protein synthesis.