Sentence examples for lead to poor efficacy from inspiring English sources

The lack of Fc FcR interactions in a subcutaneous murine model leads to poor activation of human Fc-mediated antibody dependent cellular cytotoxicity and complement dependent cytotoxicity-mediated tumor regression and could lead to poor efficacy of chimeric Rituximab.

However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics.

These latter forms of recognition can be deleterious in terms of clinical applications: proteolysis can lead to poor drug pharmacokinetics, and immunological neutralization can result in a loss of drug efficacy over time.

But political activity itself could lead to poor business decisions.

Fatigue slows reaction times and can lead to poor judgment.

Systematic biases and temporally inconsistent motivations lead to poor choices.

Fundamental mechanisms that lead to poor reproducibility are discussed.

Research suggests that short sleep duration and poor sleep quality lead to poor female sexual response.

Did the variability lead to poor vaccine effectiveness?

Associated psychiatry disorders can lead to poor response to therapy.

A bad choice here also can lead to poor results.