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We identified four factors that lead to pivotal experiences: (1) prolonged discontent and desire to change, (2) significant changes that increase fear or hope of future, (3) increased understanding of one's behavior and personal data, and (4) social accountability.
This approach lead to pivotal advancements in the understanding of ARDS pathophysiology, such as the mechanisms of positive end-expiratory pressure (PEEP) [ 4] and prone positioning [ 5].
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Central Coast's conservative approach barely produced a shot on target during the match but Sanfrecce were largely contained until their goal, with Mariners defender Brent Griffiths dismissed for the foul that lead to the pivotal moment.
This paper reviews the foundational basic science and translational research which lead to a pivotal multicenter randomized clinical trial in postmenopausal women with both periodontitis and systemic (skeletal) osteopenia.
In its second round this contest may lead to a pivotal choice between National Front candidate Marine Le Pen and far-left candidate Jean Luc Mélenchon.
The plot for the six episodes leapt very much wherever Adams wanted to go on the day, but led to a pivotal gag that went like this; a giant computer called Deep Thought, having spent exactly 7.5m years pondering on Life, the Universe and Everything finally and solemnly announces that the Ultimate Answer is... "Forty two".
This leads to the pivotal policy question regarding tradeoffs: Are the economic benefits of integration worth the potential costs incurred through demand inducement and overutilization?
That led to a pivotal moment for the country and the national team - the decision that a radical overhaul was needed.
This rapid surge of drug development has led to multicenter pivotal clinical trials and has resulted in novel ethical and global clinical trial concerns.
This in turn led to three pivotal randomised control trials that investigated the role of CRT.
These findings led to a pivotal phase III trial comparing sunitinib with IFN- α (Motzer et al, 2007).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com