Sentence examples for lead to perturb from inspiring English sources

Indeed, mutations in ARG81 gene may lead to perturb the arginine metabolism and change the cellular pool of nitrogenous compounds [ 54].

Accordingly, overexpression of C-terminal mutant alleles of the prokaryotic homologues of rpS5 and rpS14, S7 respectively S11, leads to perturbed ribosome function in E. coli [46].

As mentioned above, after infecting H. pylori on gastric epithelial cells, it can affect not only the proliferation of gastric epithelial cells, but also the activation of intracellular signaling, and that leads to perturbing the host's innate and adaptive immune system [ 87].

These features provided a road map for designing additional potent chemical derivatives and fragments of the original lead compounds to perturb the AKAP-Lbc and RhoA interactions.

These effects lead to the randomly perturbed signal formation operator resulting in a partial coherence of the system.

Translocation of endotoxin into the bloodstream can also lead to metabolic alterations and perturb blood metabolites by inducing a systemic inflammatory response [ 36].

have the potential to lead to toxicity when significantly perturbed.

The frequent disruption of this chromosomal locus in human malignancies suggests the presence of tumor suppressor genes which, when perturbed, lead to increased cancer susceptibility.

Either deficiency of normal heterotrimers or presence of mutant heterotrimers could lead to compromised basement membranes that perturb cell matrix signaling via cell surface receptors or growth factor-mediated cell cell signaling.

Lead (Pb) has been shown to perturb cellular calcium (Ca) homeostasis, altering sizes and flux rates of cellular pools of exchangeable Ca and impairing Ca-mediated cell processes.

In this review, we propose two hypotheses for the mechanisms by which land use change can lead to viral emergence: firstly, by perturbing disease dynamics in multihost disease systems via impacts on cross-species transmission rates (the 'perturbation' hypothesis); and secondly, by allowing exposure of novel hosts to a rich pool of pathogen diversity (the 'pathogen pool' hypothesis).