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Consequently, loss of the expressed allele will render the embryo null for the imprinted gene's function, or conversely, duplication of the expressed allele may lead to overabundance of the imprinted product leading to detrimental effects.
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Secondly, some areas, especially in the South Central regions, have experienced a great development in the recreational hunting industry, which leads to overabundance of wild ungulates in which sanitary programs cannot be implemented, leading to high prevalence of diseases [ 9, 18].
At a physiological level, this hypothesis would be consistent with the suggestion of reduced synaptic pruning in ASD (Courchesne et al., 2003; C.D. Frith, 2003), which might lead to an overabundance of neural pathways and encourage the formation of relatively separate populations specialized for different tasks, rather than the need to reuse the same circuits for multiple tasks.
That's produced a pattern I've seen on a host of similar environmental issues: A paucity of data leads to a overabundance of assertion.
That led to an overabundance of fuel for fires, natural and human induced.
That gun culture has led to an overabundance of firearms in many American households.
In addition, the advent of 80% of a global population carrying around a video and still image recording device with them daily has led to an overabundance of information and media gathering.
The chlorine that led to an overabundance of TTHM chemicals was used as a disinfectant; Flint increased the level of chlorine in its drinking water last year to fight bacteria.
If the hypothesis could be confirmed, there would still be the question whether the overexpression of the transgene led to an overabundance of its protein product and the subsequent phenotypic effects or if other mechanisms would be involved.
This may have also led to an overabundance of more resistant N. gonorrhoeae.
It is more likely TEM1/endosialin is directly or indirectly required for differentiation or maturation of the vasculature, as opposed to strict proliferation, and that lack of TEM1/endosialin protein leads to the overabundance of vessels demonstrated in the knockout mouse tumors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com