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In particular, these biomarkers typically each depend on a number of physiological factors that when altered by tumor therapy may lead to opposing effects on the biomarker response, thereby minimizing the biomarker sensitivity to therapy.
Therefore, it appears that in certain situations, the two systems may lead to opposing downstream effects (Steffan et al., 2004).
Here, we clearly demonstrate that activation of syn- and ex-NMDAR did not lead to opposing genomic responses.
10.7554/eLife.01849.006 Figure 3. RNAi-dependent knockdowns of ppk29 and sei expression lead to opposing effects on heat-induced paralysis.
Activation of Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis or differentiation, depending on the duration and strength of the external stimulation and on the cell type [ 29].
Consequently, fine differences in analogue input signals can be converted, at set thresholds, into digital outputs, which can ultimately lead to opposing or divergent outcomes (Daniels et al, 2006; Naeher et al, 2007).
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According to our assumptions, this would lead to opposed selective pressures on different AA sites within the same domain.
This resentment leads to opposing welfare programs they believe will mainly benefit minority groups.
Interpretations of available data have led to opposing 'information funneling' and 'parallel processing' hypotheses.
Previous studies led to opposing views on the significance of this splice variant.
In conclusion, Notch activation on macrophages and ECs leads to opposing effects in inflammatory neovascularization in situations such as CNV.
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