Sentence examples for lead to obliteration from inspiring English sources

The pathogenesis of SEL involves excess fat tissue deposition in the spinal canal, which can lead to obliteration of the spinal subarachnoid space.

Ascending transtentorial herniation, caused by posterior fossa lesions, is most often symmetrical and can lead to obliteration of the perimesencephalic cisterns.

By computer analysis (http://2zip.molgen.mpg.de/), the change of Leu157 to Ala in the optineurin sequence may lead to obliteration of the leucine zipper (data not shown).

Use of an organ or structure reinforces it; disuse leads to obliteration.

Progression of fibrosis leads to obliteration of the gas-exchange surface.

The characteristic histological feature of PSC is concentric periductal fibrosis ('onion-skinning') that gradually progresses and eventually leads to obliteration and loss of interlobular bile ducts.

Signet-ring cell cancer usually manifests as a scirrhous tumour of the stomach that leads to obliteration of gastric folds and diffuse thickening of the gastric wall (linitis plastica) (Fig. 1).

These include multilayering of the epithelium in premalignant hyperplastic lesions, a more rare intraepithelial cellular disorganization that often leads to obliteration of the central lumen in nonmalignant carcinomas in situ, and an even more infrequent migration of epithelial-derived tumor cells into the surrounding stromal microenvironment in invasive carcinomas [ 21].

However, one of the major disadvantages of chemotherapy and radiotherapy is their limited specificity to cancer cells, which lead to the obliteration and other damages to normal tissues and organs.

Changes include gaps between endothelial cells [ 2], apoptosis [ 3], endothelium activation with the expression of cell adhesion molecules, inflammatory cell recruitment, procoagulant state [ 4], and intimal proliferation and adventitial fibrosis, which may lead to vessel obliteration.

Repeated injections of blood into the epidural space may potentially lead to fibrosis and obliteration of the epidural space [35, 104, 105], so it is vitally important for clinicians to balance the advantages and drawbacks of repeat EBPs.