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It can lead to nonsense, however.
The normative aspect of his position here is that attempts (in the manner of some metaphysics, for example) to cut language free from the constraints of thought or vice versa lead to nonsense.
If I can brace myself for the probability that this will all lead to nonsense, I can groove on all the atmospherics along the way.
However, the FBN1 mutation in that family lead to nonsense mediated decay of the mutant transcript, not being able to exert a dominant-negative effect.
Does apelin mutation lead to nonsense mediated degradation of apelin mRNA?
In addition, transcriptional errors, mis-splicing, or even alternative splicing (Danckwardt et al., 2002; Lewis et al., 2003; Wollerton et al., 2004) also frequently lead to nonsense mutations.
Similar(48)
As it has been demonstrated that NMD features may lead to nonsense-mediated transcriptional gene silencing (NMTGS), we next tested whether snoRNA host genes were transcribed at lower rates in UPF2 null livers [31].
The c.2512C>T (p.Arg838*) mutation is predicted to lead to nonsense-mediated decay (NMD) or a truncated protein, but with preservation of the essential coiled-coil domain.
As was previously shown, nonsense mutations lead to nonsense-mediated decay of the mutant mRNA and reduced fibrillin protein synthesis [ 26- 28].
We find statistical evidence for selection pressure on avoidance of stop codon placements in ΨEs that would lead to nonsense-mediate decay.
46 The PTC mutations lead to nonsense-mediated mRNA decay, or residual expression of truncated type VII collagen polypeptides that are degraded within the cells.
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