Furthermore, activation of the IL-21 receptor leads to multiple effects on T cells, including proliferation, differentiation and activation of cytokine and chemokine production.
It is important to note that a dose from a single chemical may lead to multiple early effects, altered structure and functions, and outcomes.
Wear debris is generated over time as the articulating surfaces move against each other, and this debris can subsequently lead to multiple adverse effects including inflammatory hypersensitivity reactions, pseudotumor formation, osteolysis, and implant loosening.
Some SNPs may lead to multiple and diverse downstream effects, e.g. altered transcriptional response and manifestation of disease (Sakuntabhai et al., 2005).
Indeed, studies using radiolabeled 2,3,7,8-tetrachlorodibenzo 2,3,7,8-tetrachlorodibenzoclearly demonstrated that inhalation, ingestion, or dermal absorption results in major tissue deposits of [H]TCDD in the liver and fat (Diliberto et al. 1996) and suggest that multiple routes of exposure occur and that these exposures lead to multiple organ and systemic effects.
However, chronic exposure to glucocorticoids in patients with such disorders leads to multiple adverse effects.
Activation of platelets via PAR1 cleaved by thrombin leads to multiple downstream effects and observable phenotypic changes, including granule release and shape change characterized by extended pseudopodia.
One irrational decision can lead to multiple irrational decisions.
Multiple inheritance systems may lead to multiple "parent-offspring" relations.
