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Understanding how natural sequence variations lead to modulation of disorder is likely to be important for understanding the evolution of specificity in molecular recognition through intrinsically disordered regions (IDRs).
The results presented here demonstrate that PPF composites can be used for the controlled release of TP508 and that alterations in the composite's composition can lead to modulation of the TP508 release kinetics.
These interactions in aequeous solution lead to modulation of Earth's surface temperature, of acidity and alkalinity, and of the chemically reactive gases of the atmosphere and the hydrosphere' (p. 124).
These effector proteins are components of signaling cascades which ultimately lead to modulation of cellular functions.
Our studies raise questions as to when the consequences of FtsZ and ClpX interactions lead to modulation of Z-ring assembly in M. tuberculosis, especially since overproduction of ClpX led to only modest changes in cell length and growth rate (Fig. 6).
The conditions that lead to modulation of orexin receptor expression are incompletely defined.
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We hypothesized that advice would lead to modulations of internal valuation mechanisms engaged during choice, the effect of which we expected to be apparent both behaviorally and neurally.
Since the GABA-system is mainly inhibitory, increased AP activity leads to modulation of neuronal activity.
Current evidence suggests that binding of endogenous ligands to CD22 leads to modulation of B-cell activation by antigen.
Variation of the hydrophilicity and size of the indole 2-substituent of 3-arylthio-6-methylsulfonylindole inhibitors led to modulation of the COX-2 human whole blood (HWB) potency and selectivity.
Such studies could also investigate whether it is important that the independent, irrelevant stimulus is similar to the expected stimulus (as is the case here; both stimuli were oriented gratings), or whether an expectation violation also leads to modulation of the response to stimuli with completely different features (e.g., geometrical shapes or moving dots, or even auditory stimuli).
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